Understanding the role of LSD1 in cellular processes and diseases

The new review emphasizes the key role of LSD1 (demetylase 1 specific to lysine) in the regulation of critical cellular processes and its implications for human diseases. This article sheds light on how post -translational modifications (PTMS) affect LSD1 activity, affecting its function in the regulation of genes and the progression of the disease.

LSD1 is a histone demetic that plays a significant role in the reconstruction of chromatin and gene expression by modifying histone H3 lysine. He interacts with various protein complexes, which allows him to serve both as a transcription activator and a repressor. Complicated LSD1 modifications, including phosphorylation, acetylationUbiquitation, methylation, summary and s-nitroslation, dictate its enzymatic activity, sub-cell location and stability. The disturbance of these modifications was associated with many pathological diseases, including cancer, metabolic disorders, neurological diseases, cardiovascular diseases and bone disorders.

LSD1 overexpression was observed in various tumors, where it facilitates suppression of suppressor genes of cancer and promotes the proliferation of cancer cells. Interaction LSD1 with oncogenic routes contributes to the cancer and metastasismaking him a promising therapeutic goal. In metabolic diseases, LSD1 is involved in body fat differentiation and insulin sensitivity, suggesting potential strategies of obesity and diabetes management. In addition, LSD1 is of key importance in neurological development, with an autism -related divergence, Alzheimer’s disease and abdominal hardening.

The growing number of evidence to the role of LSD1 in the expression of genes and the mechanisms of the disease opens new possibilities of targeted therapy. LSD1 inhibitors are currently being studied as potential treatment of cancer and neurological disorders, aimed at restoring normal cell function by modulating its activity. The discoveries presented in this review strengthen the importance of post -translational modifications as regulatory mechanisms and emphasize the need for further research on approaching precision medicine focused on LSD1.

Expanding our understanding of LSD1 and its modifications, these studies form the basis for developing new therapeutic strategies, offering hope for better treatment in various diseases related to LSD1 dysfunction.