The coroner warns against fatal interaction

The 34-year-old nurse in Great Britain has taken a combination of drugs for years, never suspecting the quiet danger of her daily routine. However, the recent coroner report revealed that the little -known, fatal drug interaction was responsible for her sudden heartbeat and death.

Chloé Burgess from Southampton in England took antidepressants of amitriptyline (three-cyclic antidepressant) and paroxetine (selective retotonin-receptak (SSRI) inhibitors, before the doctors prescribed it Ivabradina. She received Ivabradin, heart drugs which makes the left heart. Branch block, a condition that disturbs the electrical signals of the heart.

A recent investigation into her unexplained death in 2023 revealed that her heart drugs were probably affected by her antidepressant, causing an elevated level of amitriptyline in the blood. Burgess has been accepting this combination for four years without problems. However, the episode of sleep apnea could cause heavy arrhythmia of the heart and the sudden death of the heart, the coroner report revealed.

“The potential dangers associated with the combination of amitriptylin, paroxetine and ivabradine are not widely appreciated and do not cause a software warning used to prescribe used in basic healthcare or by pharmacists,” Koroner Nicholas Walker said in the report.

Based on the findings of investigations, the Koroner issued a clear warning for doctors and healthcare employees, emphasizing the importance of having a “full understanding” of potential risk when prescribing Ivabradin along with antidepressants.

“The potential dangers associated with the combination of drugs in the case of Chloe were not well known or appreciated by its treatment … I am also afraid that people prescribing Ivabradin should fully understand the potential interaction with amitriptyline and paroxetine,” said Walker.

According to Centers for Disease Control and Prevention (CDC), SSRIs are not suitable for everyone because they can cause problems if patients have different basic conditions or when they are taken with other drugs.

SSRIs can be a risk for people with bleeding disorders, diabetes, epilepsy, narrow angle or serious kidney, liver or heart disease. They can increase the risk of bleeding, affect blood sugar levels and deteriorate seizures in epilepsy.

Some drugs that may affect SSRIs include non -steroidal anti -inflammatory drugs (NLPZ), such as ibuprofen and anti -platelets such as low dose aspirin. Other interacting drugs are Teofiline, Klozapina, Lit, Triptans and other antidepressants, including TCA, Maois and Snri.