The new $ 15 million study is aimed at understanding the risk factors for cardiovascular and kidney disease in women

Research teams from August University, Massachusetts General Hospital and Ohio State University will conduct a project in the amount of $ 15 million devoted to the study of various risk methods of cardiovascular and kidney disease, affect women. Strategically targeted research network American Heart Association (SFRN) on cardiovascular metabolic syndromes: heterogeneity in women aims to find out why women can be more exposed to the development of cardiovascular disease and kidneys due to some unique risk factors and stages of life.

American Heart Association, a global force that changes the future of health for everyone, finances strategically concentrated research networks (SFRN) as part of its mission to be a relentless force for a world of longer, healthier life. Research teams apply for four years of program subsidies with innovative and innovative ideas to better understand cardiovascular diseases, which were influenced by every Focus SFRN, the latest of which is the cardiovascular syndrome-bidney-metabolic (CKM).

The CKM syndrome is a clinical term that describes the combined health effects of heart disease, kidney disease, diabetes and obesity that expose people to heart attack, stroke and heart failure. According to heart statistics and the American Heart Association stroke in 2025, about 1 out of 3 adults in the USA has at least three components of the CKM syndrome, which include high blood pressure, abnormal cholesterol, high levels of blood glucose (sugar), impaired kidney function and excessive body weight.

Understanding mutual combinations of cardiovascular, kidneys and metabolic states, including diabetes and obesity, is crucial, especially since many risk factors are growing. Women are historically insufficiently represented in clinical trials, so we do not understand why many of these risk factors are often more widespread and affect women differently than men. Learn more about the biological importance of some life cycles, including menopause and pregnancy, as well as social factors and the roles of community, relationships and individual behaviors can provide important insight into the development of targeted preventive strategies, adapted therapeutic approaches and ultimately help in changing the future of health for everyone. “

Keith Churchwell, MD, FAHA, President of Volunteering American Heart Association, Clinical Professor of Medicine at the Yale School of Medicine in New Haven, Connecticut and assistant professor Professor of Medicine at Vanderbilt School of Medicine in Nashville, Tennessee, Tennessee

Four -year prizes, which began on April 1, 2025, include joint research projects in all three groups. In addition, to increase the commitments of the American Heart Association in expanding diversity in clinical trials, each of the centers will cooperate with an academic institution, which primarily serves people insufficiently represented in science. Research centers and projects include:

• Augustus University – This center is managed by Dr. Jennifer Sullivan, Faha, dean of Graduate School and a professor of physiology at Medical College of Georgia at Augustysty University in Augusta, Georgia and will cover cooperation with the team from Augustusity College and Mathematics. Central teams will undertake three different projects focused on the inaccurate influence of obesity on CKM syndrome. The first study will focus on how the weight gain affects males and women differently and how aging affects metabolism in men and women. In the second project, the team will conduct research to determine whether excess fat in obesity is harmful during pregnancy, which leads to health problems for both the mother and the growing child. In the third project, the team will analyze previously collected data for many years and many people to learn more about the known risk factors of the CKM syndrome, as well as seek new risk factors and body processes that can help in understanding this state and how to prevent this. In addition, the team will talk to women and healthcare providers from various environments and experiences to assess the current knowledge and levels of interest in heart health and use this information to develop programs that can help in the treatment and prevention of diseases.
• Massachusetts General Hospital (Mass General) – This center is managed by Michael Honigberg, MD, MPP, FAHA, cardiologist and researcher at Massachusetts General Hospital as well as an assistant for a medical professor at Harvard Medical School in Boston and will cover cooperation with teams with Salem State University in Salem, Massachusetts, as well in Boston and the Medical Center University. Centrum teams will undertake three different research projects that focus on how pregnancy history and other risk factors specific to women can provide tips on the risk of women for the future CKM syndrome and heart disease. In the first project, the syndrome will test the effect of excess body weight on the placenta both in mice and people to determine whether excess weight causes the placenta produces proteins that have a harmful effect on the mother’s heart, blood vessels and kidneys. In the second research project, the team will study women with high body weight and high blood pressure during pregnancy. They test whether targeted drugs use shortly after pregnancy complicated by high blood pressure, can improve blood pressure and heart structure in a long -term perspective. In the third study, the team will analyze data from several large studies that capture various events throughout the woman’s life. They will examine how CKM health markers in pregnancy anticipate heart disease, how risk factors specific to women and the stage of CKM syndrome drive heart disease in women and how CKM health markers affect the reaction of treatment in women with heart failure. They hope that their discoveries will help improve the forecast, prevention and treatment of heart disease in women.
• Ohio State University -This percentrum will be led by Joshua Joseph, MD, MPH, FAHA, Professor of Internal Medicine and endowed with a professor of research in the field of internal medicine at the Faculty of Endocrinology, Diabetes and Metabolism at the Medical University of the University of Ohio in Columbus. Through the initiative Center Beyond One Dives All (B-fit) teams will take three different projects as a multidimensional approach to CKM Health in women. The first project-Dash-MCMH-President how different drugs work for men and women to improve heart health, using real data. The second project – food and fitness with medicine – is a study that combines healthy eating, exercises and medicine to help older women stay in the treatment of health and improve heart health. The third project – Inspire Her – is a community program that supports women in making a healthy lifestyle to improve heart health. All these projects have a common goal: helping women in healthier life by creating solutions. The team uses research, training programs and teamwork between various universities to develop better treatment methods. B-fit also conducts training programs for students and young scientists to help them become experts in the field of Heart, Kidney and Metabolic Health. In the future, this team aims to transform research into real healthcare solutions so that more women, especially those from malnourished communities, can get the necessary care.

The American Heart Association has invested almost $ 300 million in establishing 18 strategically targeted research networks, each of which was aimed at solving a key strategic problem identified by the Association’s Volunteers Board. Earlier networks examine many important topics, including prevention; hypertension; Women’s health; heart failure; obesity; vascular disease; atrial fibrillation; Arrhythmia/sudden death of the heart; Cardiometabolic diabetes/type 2 diabetes; Health technology; Cardio-Conscology; The biological influence of chronic psychosocial stress and role inflammation In cardiovascular health. Each network focuses on scientific knowledge and knowledge gaps, prevention, diagnosis and treatment of a key research topic. Three to six research centers form each network, combining researchers with specialist knowledge in the field of basic, clinical and population/behavioral sciences to find new ways of diagnosing, treating and preventing heart disease and stroke.

The financing of scientific research and discoveries through initiatives such as these awards is the cornerstone of the mission of saving the life of the Centenary of the American Heart Association. The association has currently financed over $ 5.9 billion in cardiovascular, cerebral and brain studies since 1949. The new knowledge resulting from this financing still saves life and directly affects millions of people in every corner of the USA and around the world.