Teefs associated with long-term vascular damage and deterioration of stroke results

It is known that the front teefish (PE), a serious hypertensive disorder, which affects about 3-8% of pregnant women, has a long -lasting effect on the mother’s vascular system. Women with the history of PE faces a higher risk of developing conditions, such as hypertension, hyperlipidemia, and even early cognitive disorders in later life. Because the PE causes extensive endothelial dysfunction, one of the results is its potential to increase the risk of developing severe brain complications, including stroke, during the postpartum period. However, the way PE affects the cerebral vessels after delivery remains unclear.

Previous studies of animal models of hypertension have shown that handicapped cerebral vascular circulation worsens the results of stroke. However, it is not certain whether similar circulatory disorders persist after delivery in people with the history of the EP and whether they can lead to more serious damage to the stroke.

To solve this gap, a team of scientists led by Professor Marilyn J. Cipolla from the University of Vermont, USA, induced the experimental PE in rats and examined in them the effects of transient cerebral artery obstruction (or stroke). Their findings were published in the journal April 13, 2025.

“Explains Prof. Cipoll. The team used female sprague-dawley rats, randomly divided them into two groups: one group was fed a normal diet during pregnancy (normp-pp), while the other received a high cholesterol diet in order to cause PE (EPE-PP). Postar was induced in both groups 4 to 9 months after delivery to examine the effects of earlier PE, additional, additional Separate hundreds from a distance from one group, which were not an object that was not subject to people who were not in a group for a probe probe for a probe probe examined to assess the differences in cerebrospinal function.

The study showed that rats with the history of PE (EPE-PP) had much worse stroke results compared to their counterparts NORP-PP. This included an increased heart attack and brain swelling. Further analysis showed that the intensification of the infarction in the EPE-PP group was more associated with a reduction in blood perfusion, which indicates a higher sensitivity to brain ischemia. Prof. Cipolla explains, according to their hypothesis, EPE-PP rats showed significantly increased levels of oxidative stress markers in the blood were much higher in the EPE-PP group than in the Normp-PP group, which suggests that permanent oxidative stress can contribute to worse stroke results in people with the history of PE.

Scientists also analyzed the behavior of small arteries on the surface of the brain known as pial protection, which can provide alternative blood flow paths in the case of stroke. They discovered that these vessels showed greater narrowing induced with pressure (myogeral tone) in EPE-PP rats. In addition, the diameter of the vessels in this group was clearly smaller in their active (contracted) standing compared to the passive (relaxed) state in different pressure conditions-the answer not observed in the Normp-PP rats.

To sum up, discoveries indicate that the EP has a long -term side effect on the brain vascular network, even months after pregnancy. EPE-PP rats not only experienced severe impacts, but also showed increased susceptibility to ischemia and permanent oxidative stress, as well as incorrect answers in key blood vessels involved in protective circulation. Ends prof. Cipolla.

Thanks to further research on the prolonged PE influence on the mother’s brain health, scientists can be able to discover new ways to reduce stroke damage and increase long -term well -being for women affected by this condition.