Scientists examine Hookworm proteins as potential inflammation treatment

It was a long reality that with age increased inflammation appears-so widely accepted that it was called “inflammation”. Along with this increase in chronic inflammation associated with age, there are also serious health problems, such as cardiovascular and Alzheimer. But according to new research, inflammation is not as common as previously thought.

Published today in “Stanie, there is minimal among collectors-hormitalists in the Bolivian Amazon”, the work emphasizes low inflammation in one non-Industriad community, and especially growth inflammation with a moderate level of modernization in another.

Leaded by Jacob Aronoff – a post -ate research scholar at Arizona State University’s School of Human Evolution and Social Change, an affiliate from the Institute of Human Origins and a member of the Center for Evolution and Medicine – the study was analyzed by two communities in the Bolivian Amazon: Tsimane and Mosten.

Tsimane is a community of over 17,000 people in 90 villages in the Lowlands of the Bolivian Amazon. Living the lifestyle of hunters, their daily lives are very similar to human life before the industrial revolution. This ensures a unique view of health processes and aging for people before contemporary influence appeared. Previous studies have shown that they have the healthiest hearts and the lowest indicators of Alzheimer and dementia in the world.

Benjamin Trumble, an elderly author in the article and professor at ASU’s School of Human Evolution and Social Change, serves as a co -director of the Tsimane health and life history project. The group has many years of relationships with Tsimane to collect demographic and biomedical data, and also helps to provide medical care for the community – a relationship that has been in force for over 20 years.

This last look at our human past decided to determine whether the inflammation we experience in old age is a universal, human experience.

To check if inflammation is developing, we measured a set of cytokines in the sample of older adults Tsimane to see if they grow with age – we found a minimum growth with age. “

Jacob Aronoff, Scientific Postoctor at Arizona State University

To deepen their findings, scientists also examined Mosten. Although genetically very similar to Tsimane, Moseden underwent a significant cultural change starting 300 years ago, when the Jesuit missionaries settled among them.

“They are still the same genetic group, the same language group, but Moseden now has running water, electricity and hydraulic hydraulics,” said Trumble, who is also a scientist from the Origin Human Origins Asu Institute and the basic department of the Center for Evolution and Medicine.

“They are in a sense in a place where they are not as industrialized as people living in the USA, but they are not as traditional as the population as Tsimane, which still live more like most of our human ancestors.”

This stage of modernization is an interesting opportunity to compare for scientists.

“We measured them together in the same laboratory, using the same technology, and we found clearly clearer inflammation in Moset, which suggests that inflammation – to a large extent – is a product of a industrialized lifestyle,” said Aronoff.

Inflammation is not a guarantee with age, as previously thought. Although further research is needed, it seems that it largely affects environmental factors and lifestyle, such as diet and exercises. It also shows that even small modernization affects the deviation of the human body from its family path.

“In the case of 99% of the history of humanity, we were physically active hunter collectors. Now, with a sitting urban life in the city, we are currently operating outside the” recommended manufacturer’s warranty, “said Trumble.

“By working with populations that lead a more traditional lifestyle, we can get a better idea about what the basis of human health is.”

Other possibilities may be high parasitic exposure and pathogen, something that is missing in industrialized communities, but common for Tsiman. While further tests are needed, the response of the immune system developed on the basis of parasitic exposure may play a role in the absence of inflammation related to age tsimane.

“We have eliminated most of our parasites and that’s good. We should keep it,” said Trumb.

But it can be a way in which we can use potential without negative impact.

“One of the things we could do in the future, potentially, is instead, let’s say that people infected with a hook, we could find out what proteins on the surface of the hook cells are – and what if we could transform it into a drug that people could take and cheat our immune system. Our immune system would have this problem, and then it would develop it differently.”

Just like the way we use vaccinations for viruses such as flu, in which a controlled pathogenic exposure increases the response of the immune system to combating natural exposure, the same can be true for our age -related inflammation.

Ultimately, however, there is no “silver ball”, according to Trumble, because lifestyle and diet are also the main factors contributing to inflammation.

“We have future research to look at diets, physical activity and infectious exposures that are infected with Tsiman anti -inflammatory movables. We will have to conduct many future research to find out what exactly all factors are and how they work together – explained Aronoff.