Estrogen supports kidney regeneration and protects women from a chronic disease

The new mouse test ensures that women in their reproductive years seem to be relatively protected against chronic kidney disease, which is a leading problem of public health. The study informs that the signaling regulated by estrogen promotes the regeneration of key filter cells in female kidneys. The study also combines pregnancy complications, such as failures with a failure in this regenerative process. Chronic kidney disease (CKD) – which affects over 10% of the global population – is a leading problem of public health, not only because it can lead to fatal kidney failure, but also because it increases the risk of cardiovascular disease. Over the next 20 years, CKD should become the fifth leading cause of death around the world.

Previous studies have shown that sex differences play a significant role in the progression of the disease: men are more exposed to CKD, while women of childbearing age seem to be relatively protected. Although it suggests that female sex hormones, such as progesterone and estrogen, may have a protective effect in the development of CKD, mechanisms underlying the observed gender -based differences in susceptibility to diseases remain poorly understood.

By tracking the line, sequencing of single -cell RNA and analysis of mouse models and samples of human tissue and urine, Carolina Conte and colleagues show that female kidney female has more ability to regenerate key filter cells, called sub -citches, from renal progenitor cells. The cells are regenerated by signaling depending on the estrogen receptor, which protects against kidney disease and hypertension in reproductive years. What’s more, the authors said that this effect intensified in pregnant mice as kidneys adapted to a higher work load. However, when this regenerative ability is threatened, for example in the preecution, mice mothers encounter a long -term risk of kidney disease and hypertension. At the same time, their offspring are predisposed to the poor development of the nephron, low birth weight, cardiovascular problems and kidney problems later.

According to Conte, discoveries indicate that the preeclampsia may result from the failure of the kidney progenitor cells in providing a sufficient number of subcicits, combining mother’s kidney health directly with the results of pregnancy. This link offers a new insight into the potential therapeutic capabilities.