The new study combines Covid-19 with accelerated aging of blood vessels, especially in women

The latest studies have shown that coronavirus infection can accelerate the aging of blood vessels, potentially increasing the cardiovascular risk by about five years equivalent. In the study at the European Heart Journal, it reported that the effect was the strongest in women and people with a long substitute, and that the changes tended to stabilize or decrease over time.

Scientists have analyzed data from 2390 recruited participants between September 2020 and February 2022 in 34 centers in 16 countries, including Austria, Australia, Brazil, Canada, Cyprus, France, Greece, Italy, Mexico, Norway, Turkey, Great Britain and the USA. Participants were grouped according to the intensity of Covid-19 (never infected, mild disease, hospitalized in the ward or adopted for intensive care) and passed measurements for six and twelve months after infection. The vascular age was assessed by means of cervical and femoral pulse wave speed (PWV), where higher values ​​indicate stiffer, older vessels. The analyzes took into account factors such as age and gender.

On average, people who had Covid-19 had a higher PWV than people never infected, including people with a mild disease. The differences were clear in women, while men showed a small or statistically solid change. The effect was greater in people with long substitutes. In the intensive care group, vascular stiffness returned towards the norm by 12 months. Vaccinated people showed milder changes than those unvaccinated. Scientists have noticed that an increase of about 0.5 m/SW PWV is clinically significant and approximately comparable to five years of dishes aging, which corresponds to an estimated 3% increase in cardiovascular risk in a 60-year-old woman.

“We know that Covid can directly affect the blood vessels. We think it can cause what we call early vascular aging, which means that your blood vessels are older than chronological age, and you are more susceptible to heart disease. If this is happening, we need to identify who is threatened at an early stage to prevent heart attacks and hunger,” said Professor Rosa Maria with Université Paris Cité, according to eurretal. “Women have a faster and stronger immune response, which can protect them from infections. However, the same answer can also increase vascular damage after its original infection,” said Bruno, according to Eurekalert. “There are several possible explanations of Covid vascular. The Covid-19 virus acts on specific receptors in the body, called the receptors of the enzyme 2 enzyme 2, which are present on the lining of blood vessels. The virus uses these receptors to enter and infection of cells and infection of narrow-vegetables. According to Eureklerta. They defend themselves against infections, “said Bruno.

“This large, multi-importance, prospective cohort study was recorded by 2390 participants from 34 centers in order to examine whether arterial stiffness, measured by PWV, remained in people with a recent Covid-19 infection,” said Dr. Behnood Bikdeli and colleagues. “Stratified sex analyzes revealed striking differences: Women in all Covid-19-Addatt groups had a significantly elevated PWV, with the highest height (+1.09 m/s) observed in people who require admission to the ICU,” said Bikdeli and colleagues, according to Eurekalert. “Cartesian examination states that Covid-19 ages our arteries, especially in the case of adults. The question is whether we can find modifiable goals to prevent this in future increases in infection, and relieve adverse results in people affected by Covid-19, the aging of vascular vascular,” said Bikdeli and my friends. Bruno added that vascular aging is measurable and can be solved with lifestyle changes and therapy therapies that reduce blood and cholesterol pressure, and that the team planned to follow participants to determine whether accelerated vascular aging translated into more heart and strokes.

“You have to look very carefully whether these groups were really equal to finding whether the reason for this acceleration was in Covid,” said Dominik Rath, a cardiologist from the University Hospital Tübingen, according to Stern. “After a 12-month visit, the aging processes have been relatively withdrawn-what can mean that hospitalization alone or staying in the intensive care unit also plays an important role,” said Rath, according to Stern.

“Nevertheless, the study is a certain awakening,” said Heribert Schwert, vice president of the German Heart Foundation, according to DW. “It is necessary to carefully check whether these groups were really the same to determine whether coronavirus was the cause of accelerated aging,” said Schunkert, according to DW. “Many people affected Covid infection. We wanted to avoid everything to prevent aging. This makes you sit and notice,” said Schunkert, according to Bild.

“Discoveries definitely suggest that after Cavid, the elasticity of the arteries is clearly worse than usual. It is a bit surprising that the effect was observed only in women. However, it is difficult to say what is the practical risk of arterial stiffness for arterial diseases,” said Juhani Airaksynen, retired cardiology. Intlehti love. “According to Iltalehti Rakkaus, therefore, you should manage blood pressure with lifestyle changes and, if necessary, with medicines,” said Airaksinen. He noticed that infected participants were older and generally sick than controls and that the output stiffness was unknown, which could affect the results. “The positive aspect is that some changes have improved in less than a year,” said Airaksinen, according to Iltalehti Rakkaus. He added that the pulse wave speed has been used for decades, but it is not part of the output of outpatient care.

Scientists warned that it was unclear whether the observed effect reflected large changes in several people, or slight changes in many. They suggested that higher mortality in men during a pandemic could introduce the bias of survivors, potentially masking effects in men. They also noticed that many people experienced prolonged symptoms of Covid-19, including the team after the raw Covid-19, which were affected by up to 40% of the initial people who survived, and required further research to explain the mechanisms and long-term risk.