Non -traditional risk factors related to strokes in adults under 50

Adults under the age of 50 had more than twice the risk of stroke from migraine or other non -traditional stroke risk factors, and not traditional risk, such as high blood pressure, in accordance with research published today in the SCIENTIFIC Journal of American Stroke Association, the division of American Heart Association.

Previous studies indicate that the ischemic stroke indicator (blood clot) in adults aged 18-49 is growing and driven by an adequate increase in cryptogenic highlands (lift an unknown cause) in adults without traditional risk factors, including high blood pressure, smoking, obesity, high cholesterol and type 2 devils.

Up to half all ischemic strokes in younger adults have unknown causes and are more common in women. In order to effectively prevent, cautious and routine assessment of both traditional and non -traditional risk factors in younger people is crucial. We should also carefully check people after their stroke to prevent future strokes. “

Jukka Putala, MD, PH.D., M.C., The author of the lead, author, Stroke manager at Neurocenter, Helsinki University Hospital in Helsinki, Finland

Scientists analyzed data for over 1,000 adults aged 18-49 in Europe, in the median of 41 years. Half of the participants experienced cryptogenic ischemic stroke, while half had no stroke history. The study examined the connections of 12 traditional risk factors, 10 non -traditional risk factors and five risk factors specific to women (such as pregnancy diabetes or pregnancy complications). Scientists strictly reviewed participants with a heart defect called Patent Ovale (PFO), a hole between the upper chambers of the heart. PFO is usually harmless, but it is known that it increases the chances of stroke. The study was aimed at determining which risk factors contribute to unexplained strokes.

Analysis was found:

• Traditional risk factors were more related to stroke in men and women without PFO.
• On the other hand, non -traditional risk factors, such as blood clots in the veins, migraine with aura, chronic kidney disease, chronic liver or cancer disease, were more associated with stroke among PFO tests.
• In people without PFO, every additional traditional risk factor increased the risk of stroke by 41%, while every non -traditional risk factor increased the risk of stroke by 70%.
• Risk factors associated with women also increased the risk of stroke by 70% regardless of traditional and non -traditional risk factors.
• Among the participants with PFO, each traditional risk factor increased the risk of stroke by 18%. However, after considering individual demographic factors, such as age, gender and level of education, non -traditional risk factors have doubled the chances of ischemia.

Scientists also analyzed the risk associated with assigning the studied population (determining how this will affect the disease if a specific risk factor was eliminated). To calculate the risk associated with the population, scientists analyzed each risk factor and their contribution to an increased risk separately and stated:

• In the case of impacts that occur without PFO, traditional risk factors accounted for about 65% of cases, non -traditional risk factors contributed 27%, and risk factors specific to women constituted almost 19% of cases.
• However, in the case of strokes related to PFO, traditional risk factors contributed to about 34%, non -traditional risk factors accounted for 49%, and risk factors specific to women constituted about 22%.
• In particular, migraine from the aura was a leading non -traditional risk factor associated with strokes of unknown origin, with the risk of people with PFO in relation to the population, which is a greater risk for people with PFO.

“We were surprised by the role of non-traditional risk factors, especially migraine headaches, which seems to be one of the leading risk factors in the development of strokes in younger adults,” said Putaala. “Our results should inform the health community about the development of a more adapted approach to the assessment and management of the risk factor. We should ask young women whether they have the history of migraine headaches and other non -traditional risk factors.”

Chairman American Heart Association of the Clinical Cardiology (CLCD)/Stroke Women’s Health Science Committee, Ph.D., MD, MD, MD, Faha, said: “This study is helpful because the authors present data through gender and age group. They show that recent data show that younger women may have a higher risk that younger may have younger men, men, men who usually have a risk and AGHOR AGHER. education of our patients throughout their lives. ” Madsen, who was not involved in the study, is also an associate professor, vice -chairman of the rescue medical research and the epicenter director at Robert Larner, MD College of Medicine at the University of Vermont at Burlington, Vermont.

Research restrictions include an observation examination, which means that it was an overview and analysis of existing health data on patients included in another examination or database; Therefore, the results of this study cannot prove the cause and effect. The study also consisted of risk factors reported by the patient, which could affect accuracy. In addition, 95% of participants were reported as white adults of European origin, which limits the use of results to other populations.

Study details, background and design:

• The study included 523 adults aged 18–49 (median age 41; 47.3% of women; 37.5% with PFO) who suffered a cryptogenic ischemic stroke and 523 peers of a similar age without any history of stroke.
• The purpose of the review was to assess traditional and non -traditional risk factors associated with the increased risk of cryptogenic ischemic stroke.
• Participants were included in the search for explanations of cryptogenic stroke in young people: revealing the study of triggers, causes and results (Secreto) in 19 centers in 13 European nations (Estonia, Finland, Germany, Greece, Italy, Lithuania, the Netherlands, the Netherlands, Norway, Portugal, Spain, Sweden, Turkey and United Kingdom).