People with severe allergies tolerate over 5 peanuts a day after experimental therapy

Living with heavy allergies is a daily struggle for millions, with constant fear of a threatening reaction life that could send them to an ambulance at any time. However, a new experimental therapy, which cautiously increases the daily doses of peanuts in people with severe allergies under close medical supervision, offers new hope.

Early results of study of a new approach known as oral immunotherapy show that a significant number of adult participants of clinically diagnosed nut allergies were able to consume at least five peanuts per day without reaction.

In phase 2 test With the participation of 21 adults aged 18 to 40 with a clinically diagnosed allergy to peanuts, an examination of adult nut immunotherapy (GUPI) became the first that focused only on adults with severe allergies. The goal was to check whether the daily doses of peanuts, taken as part of strict medical supervision, could be safely tolerated.

Participants began with small amounts of nut flour, only 0.8 mg served in clinical conditions. Those who tolerated the initial doses continued daily micro dosage at home, gradually increasing the amount every two weeks, from a fraction of peanuts to four all peanuts. After reaching a stable dose of 1 g per day, they undergo controlled food challenge before continuing the therapy for at least three months.

“Although nut immunotherapy is known as effective in children, the study provides preliminary evidence that adults can also be felt and that this improves the quality of life. The average tolerated dose of peanuts increased 100 times during the examination” he said The main investigator, Professor Stephen Till, from Kings College London in a press release.

At the end of the study, 67% of participants who had a severe allergy to peanuts could tolerate safely, taking up to five peanuts a day. Then they could consume peanuts every day to keep them desensitized.

Discoveries offer real hope to people with nut allergies, who often live in constant fear of accidental exposure. The main author and specialized allergy dietitian Hannah Hunter explained that daily classes such as dinner, participation in social events, and even travel planning can be a source of anxiety for people with allergies.

“Life with an allergy to peanuts is a huge burden,” said Hunter. “We found that the quality of life has improved significantly after oral immunotherapy and fear of food as well.